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Conclusion: The results indicate that the formulation of sulfacetamide in Eudragit® RL100 nanosuspension could be utilized as potential delivery system for treating ocular bacterial infections.EndNote Desktop - Referencing - Library at University of Liverpool This site attempts to protect users againstĬross-Site Request Forgeries attacks. Sucrose and Mannitol were used as cryoprotectants and exhibited good water redispersibility of the FDN. The prepared nanosuspension exhibited good stability after storage at room temperature and at 40C. Instructions to Authors in the Health Sciences (The University of Toledo) Purdue Online Writing Lab (OWL) - AMA Style. Other Citation Resources Citing Medicine, 2nd Edition: The NLM Style Guide for Authors, Editors, and Publishers. To download EndNote, visit the EndNote LibGuide. Drug entrapment efficiency of the selected batch was increased by changing the pH of the external phase and addition of polymethyl methacrylate in the formulation. EndNote is available to USD faculty, staff, and students at no additional cost. No significant chemical interactions between drug and polymer were observed in the solid state characterization of the freeze dried nanosuspension (FDN). Results: Spherical, uniform particles (size below 500 nm) with positive zeta potential were obtained. In addition, freeze drying, redispersibility and short term stability study at room temperature and at 40C were performed. Characterization of the nanosupension was performed by measuring particle size, zeta potential, Fourier Transform infrared spectra (FTIR), Differential Scanning Calorimetry (DSC), Powder X-Ray Diffraction (PXRD), drug entrapment efficiency and in vitro release.

Drug to polymer ratio was selected as formulation variable. Methods: Nanosuspensions were prepared by the solvent displacement method using acetone and Pluronic® F108 solution. Purpose: Polymeric nanosuspension was prepared from an inert polymer resin (Eudragit® RL100) with the aim of improving the availability of sulfacetamide at the intraocular level to combat bacterial infections.